Representative photomicrographs of gastric mucosa in rats (H&E staining, ×100).

<p>In rats from negative control group, normal gastric tissue has intact gastric pits and glands. Rats exposed to WRS (lesion control) have severe mucosal erosion and submucosal edema with macrophage and eosinophil infiltrates. In rats pretreated with Omeprazole (20 mg/kg), inflammatory exudates and edema can be detected in submucosal. Rats pre-treated with <i>astragaloside IV</i> have a reduction in submucosal edema and leukocyte infiltration in a dose- dependent manner (1–50 mg/kg).