Vaccines to efficiently block or limit sexual transmission of both HIV and human papilloma virus (HPV) are urgently needed. Chimeric virus-like-particle (VLP) vaccines consisting of both multimerized HPV L1 proteins and fragments of SIV gag p27, HIV-1 tat, and HIV-1 rev proteins (HPV-SHIV VLPs) were constructed and administered to macaques both systemically and mucosally. An additional group of macaques first received a priming vaccination with DNA vaccines expressing the same SIV and HIV-1 antigens prior to chimeric HPV-SHIV VLP boosting vaccinations. Although HPV L1 antibodies were induced in all immunized macaques, weak antibody or T cell responses to the chimeric SHIV antigens were detected only in animals receiving the DNA prime/HPV-SH...
Further advances are required in understanding protection from AIDS by T cell immunity across mucosa...
Further advances are required in understanding protection from AIDS by T cell immunity across mucosa...
AbstractIn the search for an effective vaccine against the human immunodeficiency virus (HIV), novel...
AbstractVaccines to efficiently block or limit sexual transmission of both HIV and human papilloma v...
Currently available prophylactic vaccines have no therapeutic efficacy for preexisting human papillo...
Virus-like particles (VLPs) are a type of subunit vaccine which resembles viruses but do not contain...
The current HIV pandemic has killed more than 35 million people since 1985, and infects a further 30...
AbstractWe earlier reported that immunization of macaques with a reverse transcriptase-deleted SHIVK...
Producing a prophylactic vaccine for human immunodeficiency virus (HIV) has proven to be a challenge...
A preventive human immunodeficiency virus type 1 (HIV-1) vaccine is an essential part of the strateg...
Induction of HIV-specific T-cell responses by vaccines may facilitate efficient control of HIV. Plas...
UnlabelledThe encouraging results of the RV144 vaccine trial have spurred interest in poxvirus prime...
Major histocompatibility complex (MHC) molecules expressed on the surface of human immunodeficiency ...
Immunization with human papillomavirus (HPV) L1 virus-like particles (VLPs) prevents infection with ...
Millions of people have died from AIDS worldwide and many more are currently living with HIV infecti...
Further advances are required in understanding protection from AIDS by T cell immunity across mucosa...
Further advances are required in understanding protection from AIDS by T cell immunity across mucosa...
AbstractIn the search for an effective vaccine against the human immunodeficiency virus (HIV), novel...
AbstractVaccines to efficiently block or limit sexual transmission of both HIV and human papilloma v...
Currently available prophylactic vaccines have no therapeutic efficacy for preexisting human papillo...
Virus-like particles (VLPs) are a type of subunit vaccine which resembles viruses but do not contain...
The current HIV pandemic has killed more than 35 million people since 1985, and infects a further 30...
AbstractWe earlier reported that immunization of macaques with a reverse transcriptase-deleted SHIVK...
Producing a prophylactic vaccine for human immunodeficiency virus (HIV) has proven to be a challenge...
A preventive human immunodeficiency virus type 1 (HIV-1) vaccine is an essential part of the strateg...
Induction of HIV-specific T-cell responses by vaccines may facilitate efficient control of HIV. Plas...
UnlabelledThe encouraging results of the RV144 vaccine trial have spurred interest in poxvirus prime...
Major histocompatibility complex (MHC) molecules expressed on the surface of human immunodeficiency ...
Immunization with human papillomavirus (HPV) L1 virus-like particles (VLPs) prevents infection with ...
Millions of people have died from AIDS worldwide and many more are currently living with HIV infecti...
Further advances are required in understanding protection from AIDS by T cell immunity across mucosa...
Further advances are required in understanding protection from AIDS by T cell immunity across mucosa...
AbstractIn the search for an effective vaccine against the human immunodeficiency virus (HIV), novel...