zQ175 mice displayed progressive motor deficits on balance beam and decreased locomotor activity in the Open Field chambers.

<p>(<b>A,B</b>) Mice were trained and tested on a 5 mm balance beam (A) or 11 mm beam (B), and latency to cross the beam was recorded. n = 16, 8 male and 8 female homozygous zQ175 mice. *<i>p</i><0.05 versus age matched wild type (WT) mice by repeated two-way (Age and Genotype) <i>ANOVA</i>. (<b>C-E)</b> Locomotor activity was assessed in the Open Field apparatus; total activity (C), central activity (D), and rearing frequency (E) were recorded automatically during a 1 h testing period. n = 16, 8 males and 8 females. *<i>p</i><0.05 versus age-matched wild type (WT) mice by one-way <i>ANOVA</i> with Fisher’s <i>posthoc</i> tests. (<b>F</b>) Time staying on the rotarod was recorded and averaged among three trials. n = 16, 8 males and 8 females. *<i>p</i><0.05 versus age-matched wild type (WT) mice by one-way <i>ANOVA</i> with Fisher’s <i>posthoc</i> tests.