<i>Fc</i>^<i>+</i><i>Pik3ca</i>^{<i>H1047R</i>} colon cancers are similar to those in <i>Fc</i>^<i>+</i> <i>Pik3c</i>a^<i>p110*</i> mice.

<p>In both of these <i>Pik3ca</i> mutant models, deeply invasive cancers are seen with the vast majority of the tumors having penetrated below the muscularis mucosa. This is in contrast to <i>Apc</i>^<i>Min</i> colon tumors, which typically are adenomatous tumors with no or just superficial invasion. Abundant mucin is present within both the <i>Fc</i>^<i>+</i> <i>Pik3ca</i>^{<i>H1047R</i>} and <i>Fc</i>^<i>+</i> <i>Pik3c</i>a^<i>p110*</i> colon cancers. These <i>Pik3ca</i> mutant cancers also demonstrate increased proliferation, as measured by nuclear Ki67, in comparison to <i>Apc</i>^<i>Min</i> tumors. In addition, phosphorylated RPS6 and ERK1/2 are increased above that seen in the <i>Apc</i>^<i>Min</i> colon lesions. Scale bar for low magnification images = 1mm. Enlargements are 10x magnifications of the areas outlined in the low magnification images. Min, <i>Apc</i>^<i>Min</i>.