Analysis of DEGs present in the continuous expression group.

<p><u>Panel A:</u> Plot of gene expression averaged from 3 biological replicates for those DEGs found to be up-regulated (red) or down-regulated (blue) between 2 and 5 hrs of MET treatment. Expression values beyond the means for each group at each time point are shown as single points either above or below the error bars. <u>Panel B</u>: Representative GO categories enriched for the up-regulated genes are shown. <u>Panel C</u>: Representative GO categories showing enrichment for the down-regulated genes are shown. For both Panels B and C, length of bar corresponds to degree of significance (longer bars = greater significance), <i>p</i>-values determined by Benjamini-Hochberg procedure.