Association of <i>ADH1B</i> genotype with risk of upper aerodigestive cancer.

<p>Risk of upper aerodigestive cancer by <i>ADH1B</i> genetic variation, stratified by drinking intensity and smoking status, is shown as the odds ratio (OR) of upper aerodigestive cancer by re1229984 (<i>ADH1B</i>) genotype comparing rare allele (dominant model) carriers versus common allele homozygous genotype. ORs are standardised by age, sex, study centre, cumulative alcohol consumption, and, when relevant, smoking. ORs and 95% CI are derived from fixed effects models. <i>Figure adapted from Hashibe et al</i>. <i>(2008)</i> [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005765#pgen.1005765.ref057" target="_blank">57</a>] <i>with permission granted by Nature Publishing Group</i>.