Atherosclerotic plaque size and composition after 12 weeks of HFD in EKO vs DKO mice.

<p>Plaque size and composition in EKO vs DKO mice fed a HFD for 12 weeks. (A) AS and BCA plaques were taken from EKO (N = 15) and DKO (N = 10–11) mice. A) Average plaque areas were quantified from the 12 near serial sections subjected to EVG or other cell-specific or other stains. (B) Oil-red-O staining was used to stain for lipids <i>en face</i> and the percentage area of lipids in whole aortae was quantified (N = 10). Further sections of AS and BCA plaque were stained for the presence of (C) macrophages (GSL I) and (D) smooth muscle cells (SMA). Values are expressed as mean ± SEM. * P<0.05.