Metabolites whose cellular contents were suppressed by M₄N treatment in common with three cell lines (LNCaP, AsPC-1, and L428).

<p>LNCaP, AsPC-1 and L428 cells were treated with M₄N (80μM) for 8 h and metabolite contents of the samples were measured by LC/GC mass spectroscopy by Metabolon (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0148685#pone.0148685.s003" target="_blank">S1 Table</a>). Among the metabolites examined, only the metabolites whose contents were significantly (p≤0.05) suppressed by M₄N in at least two out of three cell lines were selected and listed here under the additional condition that the effect of M₄N on the contents of metabolites in the third cell line was a suppression, no significant change, or not examined. 'M/C' indicates the ratio of metabolite contents for the samples treated with M₄N vs. control. N.A. indicates 'data not available'. The exceptions for these rules were ADP and UDP-glucose (whose contents were both suppressed by M₄N in two of the three cell lines but the difference was statistically significant only in one of the two cell lines. In the third cell line the data was not available). The numbers for the ratio shaded in green indicate that metabolite contents were statistically smaller in the treated samples than the control while those without shades indicate that there was not a statistical difference between the control and the treated samples.