<div><p>Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor heterogeneity is observed, from which we inferred the evolutionary history of the tumors. First, clonally shared alterations appeared, in which C>T transitions at CpG site and CpG island hypermethylation were relatively enriched. Correlation between mutation counts and patients’ ages suggests that the early-acquired alterations resulted from aging. In the late phase, a parental clone was branched into numerous subclones. Known driver alterations were observed freq...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
Abstract Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC ha...
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; h...
Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC has progres...
Summary: Tumor multiregion sequencing reveals intratumor heterogeneity (ITH) and clonal evolution pl...
Background The classical genetic model of colorectal cancer presents APC mutations as the earliest g...
<p>First, founder alterations containing a set of drive alterations are accumulated in the genome an...
How and when tumoral clones start spreading to surrounding and distant tissues is currently unclear....
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
Abstract Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC ha...
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; h...
Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC has progres...
Summary: Tumor multiregion sequencing reveals intratumor heterogeneity (ITH) and clonal evolution pl...
Background The classical genetic model of colorectal cancer presents APC mutations as the earliest g...
<p>First, founder alterations containing a set of drive alterations are accumulated in the genome an...
How and when tumoral clones start spreading to surrounding and distant tissues is currently unclear....
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant...