Simulation of vascular tumor.

<p>Hypoxic tumor cells (dark brown; see color scales in the bottom left corner) release tumor angiogenic factor (not shown in the plot for clarity) that promotes the growth of capillaries (red). The new vasculature brings additional nutrients (blue scale) to the tumor favoring its growth (see the tumor area evolution in the top right inset). The top left inset shows through contour lines the time evolution of the tumor and the capillaries that have penetrated it. The bottom right inset shows a tip endothelial cell that is about to anastomose with other capillary and the nutrient distribution in the surroundings of the neovasculature. As expected, the nutrient concentration decreases with the distance to the capillaries.