Regeneration of zebrafish (Danio rerio, F. Hamilton, 1822)

Ograničeni regenerativni kapacitet nekoliko organa u sisavaca, kao što su središnji živčani sustav, srce i udovi čine liječenje teških bolesti vrlo teškim. Zato je razumijevanje staničnih i molekulanih mehanizama regeneracije organa od velikog znanstvenog i kliničkog interesa. Veliki napredak je već napravljen nakon iscrpnih istraživanja napravljenih pomoću različitih modelnih organizama. Nažalost još nam nedostaje znanja kako bi dostigli zadani cilj. Nedavno je zebrica postala popularni modelni organizam za regeneraciju. Razlog tomu je njezin veliki regenerativni kapacitet, posebno onih organa koji se slabo regeneriraju u sisavaca. Osim toga imaju još neke karakteristike koje su zgodne za istraživanje regeneracije organa. Ovaj rad je osvrt na dosadašnji napredak na područiju regeneracije organa zebrice, posebno regeneracije peraje, srca, CNS-a i jetre. Također se diskutiraju razlozi zbog kojih je regenerativni kapacitet kralježnjaka smanjen, uloge upalnog procesa tokom regeneracije i razlike između organogeneze i ontogeneze.The limited regenerative capacity of several organs, such as central nervous system (CNS), heart and limb in mammals makes related major diseases quite difficult to recover. Therefore, knowledge of the cellular and molecular mechanisms underlying organ regeneration is of great scientific and clinical interests. Tremendous progression has already been made after extensive investigations using several model organisms for decades. Unfortunately, distance to the final achievement of the goal still remains. Recently, zebrafish became a popular model organism for the deep understanding of regeneration based on its powerful regenerative capacity, in particular the organs that are limitedly regenerated in mammals. Additionally, zebrafish are endowed with other advantages good for the study of organ regeneration. This review summarizes the recent progress in the study of zebrafish organ regeneration, in particular regeneration of fin, heart, CNS, and liver. There are also discussions about reasons of the reduced regenerative capacity in higher vertebrates, the roles of inflammation during regeneration, and the difference between organogenesis and regeneration