Accurate measurement of the tissue pH in vivo by MRI may be of clinical value for both diagnosis and selection/monitoring of therapy. To act as pH reporters, MRI contrast agents have to provide responsiveness to pH that does not require prior knowledge of the actual concentration of the contrast agent. This work deals with the use of a paramagnetic gadolinium(III) complex, loaded into liposomes, whose relaxometric properties are affected by the pH of the medium. In this system, the amphiphilic metal complex, which contains a moiety whose protonation changes the coordination properties of the metal chelate, experiences a different intraliposomial distribution depending on the pH conditions. The pH of the solution can be unambiguously identi...
A major application of molecular MR imaging is receptor mapping of cells lining blood vessels with t...
Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment de...
Introduction Calcium responsive contrast agents could be considered of great interest in MRI as they...
Accurate measurement of the tissue pH in vivo by MRI may be of clinical value for both diagnosis and...
Alterations in extracellular tissue pH accompany many disease processes, such as cancer, inflammatio...
The measurement of extracellular pH (pHe ) has significant clinical value for pathological diagnoses...
Paramagnetic liposomes, spherical particles formed by a lipid bilayer, are able to accommodate a hig...
The magnetic resonance imaging (MRI) performance of two liposome formulations incorporating amphiphi...
ABSTRACT This work is focused on the synthesis of a family of new macrocyclic ligands with exchangea...
The relaxometric properties of two biotinylated paramagnetic liposomes with different lipophilic com...
One of the major challenges of MR imaging is the quantification of local concentrations of contrast ...
TÁBORSKÁ, Z. New ligands for magnetic resonance imaging; pH-sensitive probes. Prague: Charles Univer...
A major application of molecular MR imaging is receptor mapping of cells lining blood vessels with t...
Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment de...
Introduction Calcium responsive contrast agents could be considered of great interest in MRI as they...
Accurate measurement of the tissue pH in vivo by MRI may be of clinical value for both diagnosis and...
Alterations in extracellular tissue pH accompany many disease processes, such as cancer, inflammatio...
The measurement of extracellular pH (pHe ) has significant clinical value for pathological diagnoses...
Paramagnetic liposomes, spherical particles formed by a lipid bilayer, are able to accommodate a hig...
The magnetic resonance imaging (MRI) performance of two liposome formulations incorporating amphiphi...
ABSTRACT This work is focused on the synthesis of a family of new macrocyclic ligands with exchangea...
The relaxometric properties of two biotinylated paramagnetic liposomes with different lipophilic com...
One of the major challenges of MR imaging is the quantification of local concentrations of contrast ...
TÁBORSKÁ, Z. New ligands for magnetic resonance imaging; pH-sensitive probes. Prague: Charles Univer...
A major application of molecular MR imaging is receptor mapping of cells lining blood vessels with t...
Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment de...
Introduction Calcium responsive contrast agents could be considered of great interest in MRI as they...