<p>(A, B) The mRNA expression of the indicated genes in the pancreas of <i>Mafk</i>-Tg relative to WT at E15.5 (n = 6 per each) *<i>P</i> < 0.05, **<i>P</i> < 0.01. The error bars represent the standard errors of the means. (A) Genes involved in hormone processing and secretion. (B) Transcription factors related to the endocrine development. (C) Immunohistochemical staining of Insulin and ARX of WT and <i>Mafk</i>-Tg mice at E15.5. Scale bars = 40 μm. (D) The average number of cells that appeared positive for ARX immunostaining per pancreatic section at E15.5 (n: WT = 3, <i>Mafk</i>-Tg = 3).</p
<p>The number of correctly, incorrectly and ambiguously explained gene expression observations are g...
<p>P5 pancreatic sections were stained for glucagon (blue), Arx (red), and YFP (green). (<b>A</b>): ...
<p>(<b>A–F</b>): Control and ArxE E15.5 pancreatic sections were stained for glucagon (green) and in...
<p>The data are presented as the fold-change in gene expression relative to the value in the transfe...
<p>Images show immuno-stainings for insulin (<b>A</b>, <b>B</b>), glucagon (<b>C</b>, <b>D</b>), and...
<p>Total pancreatic RNA was prepared from Atoh8 Δ<sup>panc</sup> and control embryos at (E)15.5. Gen...
(A–G) Gene regulatory networks underlying endocrine cell clustering relating to differentiation and ...
<p>At E17.5 Isl1 (green, <b>AB</b>), Pax6 (green, <b>CD</b>) and Hb9 (green, <b>EF</b>), transcripti...
<p>Mean ± SEM relative expression level of genes in CD133+ cells compared to the CD133-depleted (CD1...
<p>(A) Normalized expression values of Prdm16 in sorted cells. (B) Normalized expression values of B...
<p>(A, B) Schematic of the transgenes for conditional <i>Nkx6.1</i> misexpression and cell lineage t...
AbstractMajor insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important r...
<p><b>A</b>. Histological examination of pancreatic tissue from pups (p15) with Hematoxylin/Eosin st...
<p>(A) Double immunohistochemistry with anti-insulin and anti-glucagon antibodies were conducted in ...
Pancreatic endocrine cell differentiation depends on transcription factors that also contribute in a...
<p>The number of correctly, incorrectly and ambiguously explained gene expression observations are g...
<p>P5 pancreatic sections were stained for glucagon (blue), Arx (red), and YFP (green). (<b>A</b>): ...
<p>(<b>A–F</b>): Control and ArxE E15.5 pancreatic sections were stained for glucagon (green) and in...
<p>The data are presented as the fold-change in gene expression relative to the value in the transfe...
<p>Images show immuno-stainings for insulin (<b>A</b>, <b>B</b>), glucagon (<b>C</b>, <b>D</b>), and...
<p>Total pancreatic RNA was prepared from Atoh8 Δ<sup>panc</sup> and control embryos at (E)15.5. Gen...
(A–G) Gene regulatory networks underlying endocrine cell clustering relating to differentiation and ...
<p>At E17.5 Isl1 (green, <b>AB</b>), Pax6 (green, <b>CD</b>) and Hb9 (green, <b>EF</b>), transcripti...
<p>Mean ± SEM relative expression level of genes in CD133+ cells compared to the CD133-depleted (CD1...
<p>(A) Normalized expression values of Prdm16 in sorted cells. (B) Normalized expression values of B...
<p>(A, B) Schematic of the transgenes for conditional <i>Nkx6.1</i> misexpression and cell lineage t...
AbstractMajor insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important r...
<p><b>A</b>. Histological examination of pancreatic tissue from pups (p15) with Hematoxylin/Eosin st...
<p>(A) Double immunohistochemistry with anti-insulin and anti-glucagon antibodies were conducted in ...
Pancreatic endocrine cell differentiation depends on transcription factors that also contribute in a...
<p>The number of correctly, incorrectly and ambiguously explained gene expression observations are g...
<p>P5 pancreatic sections were stained for glucagon (blue), Arx (red), and YFP (green). (<b>A</b>): ...
<p>(<b>A–F</b>): Control and ArxE E15.5 pancreatic sections were stained for glucagon (green) and in...