Synthesis of 2-(Trifluoromethyl)oxazoles from β-Monosubstituted Enamines via PhI(OCOCF3)2-Mediated Trifluoroacetoxylation and Cyclization

PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3

Wang, Yi-Feng
Lonca, Geoffroy Hervé
Chiba, Shunsuke

January 2014

The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and ...

Additive-Free Three-Component Synthesis of Spiro-isoxazolidine-oxindoles Employing Trifluorodiazoethane

Ekta Gupta (535573)
Sindoori R. Nair (5999963)
Ruchir Kant (1433839)
Kishor Mohanan (1433842)

November 2018

An efficient three-component protocol for the synthesis of trifluoromethylated spiro-isoxazolidine-o...

Formation of Functionalized 2H‑Azirines through PhIO-Mediated Trifluoroethoxylation and Azirination of Enamines

Xiaoqian Sun (211911)
Youran Lyu (1867675)
Daisy Zhang-Negrerie (1490686)
Yunfei Du (1490683)
Kang Zhao (407195)

December 2013

A variety of enaminones and enamine carboxylic esters were converted to trifluoroethoxylated 2H</...

Synthesis of 2-(Trifluoromethyl)oxazoles from β-Monosubstituted Enamines via PhI(OCOCF3)2-Mediated Trifluoroacetoxylation and Cyclization

Feifei Zhao (153044)
Xin Liu (43569)
Rui Qi (1404634)
Daisy Zhang-Negrerie (1490686)
Jianhui Huang (467132)
Yunfei Du (1490683)
Kang Zhao (407195)

February 2016

Treatment of β-monosubstituted enamines with phenyliodine bis(trifluoroacetate) (PIFA) was found to...

Synthesis of 2‑Fluoroalkylated Oxazoles from β‑Monosubstituted Enamines via Fluoroacyloxylation and Cyclization Mediated by Fluoroalkyl-Containing Hypervalent Iodine(III) Species Generated In Situ

Zhifang Yang (1604266)
Fengxia Sun (1754209)
Yadong Li (317794)
Kaiyue Yang (12815476)
Jianing Zhang (283045)
Lingzhi Xu (436885)
Hui Zhao (7395)
Yunfei Du (1490683)

July 2023

A metal-free synthesis of a series of fluoroalkyl-containing oxazoles from β-monosubstituted enamine...

Synthesis of Oxazoles from Enamides via Phenyliodine Diacetate-Mediated Intramolecular Oxidative Cyclization

Yunhui Zheng (2022763)
Xuming Li (721122)
Chengfeng Ren (2022766)
Daisy Zhang-Negrerie (1490686)
Yunfei Du (1490683)
Kang Zhao (407195)

November 2012

A group of functionalized oxazoles were synthesized in moderate to good yields from enamides via phe...

Synthesis of optically active trifluoromethyl-substituted 2,3-dihydroimidazo[2,1-b]oxazoles

Mlostoń, Grzegorz
Wroblewska, Aneta
Heimgartner, Heinz

July 2016

The 2-unsubstituted imidazole N-oxides with a 3,3,3-trifluoro-2-hydroxypropyl group at N(1) in the p...

Preparation of 2,4,5-Trisubstituted Oxazoles through Iodine-mediated Aerobic Oxidative Cyclization of Enaminones

Yunxiang Weng (1555066)
Weiwei Lv (754105)
Jia Yu (220212)
Bailu Ge (4975223)
Guolin Cheng (1555069)

March 2018

A novel approach to trisubstituted oxazoles has been developed that is based upon an iodine-mediated...

Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles

Akio Saito

September 2012

In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf2N...

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.

Poh, Jian Siang
García-Ruiz, Cristina
Zúñiga, Andrea
Meroni, Francesca
Blakemore, David C
Browne, Duncan L
Ley, Steven

July 2016

We report conditions for the preparation of a range of trifluoromethylated isoxazole building blocks...

α,β-Disubstituted CF3-Enones as a Trifluoromethyl Building Block: Regioselective Preparation of Totally Substituted 3-CF3-Pyrazoles

Muzalevskiy V.M.
Sizova Z.A.
Panyushkin V.V.
Chertkov V.A.
Khrustalev V.N.
Nenajdenko V.G.

An efficient pathway toward a novel class of trifluoromethyl building blocks was elaborated. The rea...

α,β-Disubstituted CF3-Enones as a Trifluoromethyl Building Block: Regioselective Preparation of Totally Substituted 3-CF3-Pyrazoles

Muzalevskiy V.M.
Sizova Z.A.
Panyushkin V.V.
Chertkov V.A.
Nenajdenko V.G.
Khrustalev V.N.

An efficient pathway toward a novel class of trifluoromethyl building blocks was elaborated. The rea...

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation

Poh, J-S
Garcia-Ruiz, C
Zuniga, A
Meroni, F
Blakemore, DC
Browne, DL
Ley, SV

January 2016

We report conditions for the preparation of a range of trifluoromethylated isoxazole building blocks...

Direct β‑Acyloxylation of Enamines via PhIO-Mediated Intermolecular Oxidative C–O Bond Formation and Its Application to the Synthesis of Oxazoles

Xin Liu (43569)
Ran Cheng (579717)
Feifei Zhao (153044)
Daisy Zhang-Negrerie (1490686)
Yunfei Du (1490683)
Kang Zhao (407195)

November 2012

A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an ...

Regioselective synthesis of 5-trifluoromethyl-1,2,3-triazoles via CF 3-directed cyclization of 1-trifluoromethyl-1,3-dicarbonyl compounds with azides

Rozin, Yu. A.
Leban, Johann
Dehaen, Wim
Nenajdenko, Valentine G.
Muzalevskiy, Vasiliy M.
Eltsov, Oleg S.
Bakulev, Vasiliy A.

January 2012

1-Trifluoromethyl-substituted 1,3-dicarbonyl compounds are shown to undergo 100% regioselective cycl...

PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3

Wang, Yi-Feng
Lonca, Geoffroy Hervé
Chiba, Shunsuke

January 2014

The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and ...

Additive-Free Three-Component Synthesis of Spiro-isoxazolidine-oxindoles Employing Trifluorodiazoethane

Ekta Gupta (535573)
Sindoori R. Nair (5999963)
Ruchir Kant (1433839)
Kishor Mohanan (1433842)

November 2018

An efficient three-component protocol for the synthesis of trifluoromethylated spiro-isoxazolidine-o...

Formation of Functionalized 2H‑Azirines through PhIO-Mediated Trifluoroethoxylation and Azirination of Enamines

Xiaoqian Sun (211911)
Youran Lyu (1867675)
Daisy Zhang-Negrerie (1490686)
Yunfei Du (1490683)
Kang Zhao (407195)

December 2013

A variety of enaminones and enamine carboxylic esters were converted to trifluoroethoxylated 2H</...

Synthesis of 2-(Trifluoromethyl)oxazoles from β-Monosubstituted Enamines via PhI(OCOCF3)2-Mediated Trifluoroacetoxylation and Cyclization

Feifei Zhao (153044)
Xin Liu (43569)
Rui Qi (1404634)
Daisy Zhang-Negrerie (1490686)
Jianhui Huang (467132)
Yunfei Du (1490683)
Kang Zhao (407195)

February 2016

Treatment of β-monosubstituted enamines with phenyliodine bis(trifluoroacetate) (PIFA) was found to...

Synthesis of 2‑Fluoroalkylated Oxazoles from β‑Monosubstituted Enamines via Fluoroacyloxylation and Cyclization Mediated by Fluoroalkyl-Containing Hypervalent Iodine(III) Species Generated In Situ

Zhifang Yang (1604266)
Fengxia Sun (1754209)
Yadong Li (317794)
Kaiyue Yang (12815476)
Jianing Zhang (283045)
Lingzhi Xu (436885)
Hui Zhao (7395)
Yunfei Du (1490683)

July 2023

A metal-free synthesis of a series of fluoroalkyl-containing oxazoles from β-monosubstituted enamine...

Synthesis of Oxazoles from Enamides via Phenyliodine Diacetate-Mediated Intramolecular Oxidative Cyclization

Yunhui Zheng (2022763)
Xuming Li (721122)
Chengfeng Ren (2022766)
Daisy Zhang-Negrerie (1490686)
Yunfei Du (1490683)
Kang Zhao (407195)

November 2012

A group of functionalized oxazoles were synthesized in moderate to good yields from enamides via phe...

Synthesis of optically active trifluoromethyl-substituted 2,3-dihydroimidazo[2,1-b]oxazoles

Mlostoń, Grzegorz
Wroblewska, Aneta
Heimgartner, Heinz

July 2016

The 2-unsubstituted imidazole N-oxides with a 3,3,3-trifluoro-2-hydroxypropyl group at N(1) in the p...

Preparation of 2,4,5-Trisubstituted Oxazoles through Iodine-mediated Aerobic Oxidative Cyclization of Enaminones

Yunxiang Weng (1555066)
Weiwei Lv (754105)
Jia Yu (220212)
Bailu Ge (4975223)
Guolin Cheng (1555069)

March 2018

A novel approach to trisubstituted oxazoles has been developed that is based upon an iodine-mediated...

Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles

Akio Saito

September 2012

In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf2N...

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.

Poh, Jian Siang
García-Ruiz, Cristina
Zúñiga, Andrea
Meroni, Francesca
Blakemore, David C
Browne, Duncan L
Ley, Steven

July 2016

We report conditions for the preparation of a range of trifluoromethylated isoxazole building blocks...

α,β-Disubstituted CF3-Enones as a Trifluoromethyl Building Block: Regioselective Preparation of Totally Substituted 3-CF3-Pyrazoles

Muzalevskiy V.M.
Sizova Z.A.
Panyushkin V.V.
Chertkov V.A.
Khrustalev V.N.
Nenajdenko V.G.

An efficient pathway toward a novel class of trifluoromethyl building blocks was elaborated. The rea...

α,β-Disubstituted CF3-Enones as a Trifluoromethyl Building Block: Regioselective Preparation of Totally Substituted 3-CF3-Pyrazoles

Muzalevskiy V.M.
Sizova Z.A.
Panyushkin V.V.
Chertkov V.A.
Nenajdenko V.G.
Khrustalev V.N.

An efficient pathway toward a novel class of trifluoromethyl building blocks was elaborated. The rea...

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation

Poh, J-S
Garcia-Ruiz, C
Zuniga, A
Meroni, F
Blakemore, DC
Browne, DL
Ley, SV

January 2016

We report conditions for the preparation of a range of trifluoromethylated isoxazole building blocks...

Direct β‑Acyloxylation of Enamines via PhIO-Mediated Intermolecular Oxidative C–O Bond Formation and Its Application to the Synthesis of Oxazoles

Xin Liu (43569)
Ran Cheng (579717)
Feifei Zhao (153044)
Daisy Zhang-Negrerie (1490686)
Yunfei Du (1490683)
Kang Zhao (407195)

November 2012

A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an ...

Regioselective synthesis of 5-trifluoromethyl-1,2,3-triazoles via CF 3-directed cyclization of 1-trifluoromethyl-1,3-dicarbonyl compounds with azides

Rozin, Yu. A.
Leban, Johann
Dehaen, Wim
Nenajdenko, Valentine G.
Muzalevskiy, Vasiliy M.
Eltsov, Oleg S.
Bakulev, Vasiliy A.

January 2012

1-Trifluoromethyl-substituted 1,3-dicarbonyl compounds are shown to undergo 100% regioselective cycl...

PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3

Wang, Yi-Feng
Lonca, Geoffroy Hervé
Chiba, Shunsuke

January 2014

The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and ...

Additive-Free Three-Component Synthesis of Spiro-isoxazolidine-oxindoles Employing Trifluorodiazoethane

Ekta Gupta (535573)
Sindoori R. Nair (5999963)
Ruchir Kant (1433839)
Kishor Mohanan (1433842)

November 2018

An efficient three-component protocol for the synthesis of trifluoromethylated spiro-isoxazolidine-o...

Formation of Functionalized 2H‑Azirines through PhIO-Mediated Trifluoroethoxylation and Azirination of Enamines

Xiaoqian Sun (211911)
Youran Lyu (1867675)
Daisy Zhang-Negrerie (1490686)
Yunfei Du (1490683)
Kang Zhao (407195)

December 2013

A variety of enaminones and enamine carboxylic esters were converted to trifluoroethoxylated 2H</...

Synthesis of 2-(Trifluoromethyl)oxazoles from β-Monosubstituted Enamines via PhI(OCOCF<sub>3</sub>)<sub>2</sub>-Mediated Trifluoroacetoxylation and Cyclization

Abstract

Extracted data

Synthesis of 2-(Trifluoromethyl)oxazoles from β-Monosubstituted Enamines via PhI(OCOCF<sub>3</sub>)<sub>2</sub>-Mediated Trifluoroacetoxylation and Cyclization

Abstract

Extracted data

Topics

Related items

Topics

Related items