Pneumococcal-specific antibody titers after vaccination.

<p>PPS3-specific total IgG (A), IgG3 (B), and IgM (C) antibody titers were measured by ELISA in Prevnar-13 vaccinated 2–3 month old control and SCD mice at weeks 0 (before vaccination), 4, 9, and 14. * = <i>p</i> < 0.05 and ** = <i>p</i> <0.01 for between groups comparisons at the same time point (as determined using a two-tailed Student’s T-test) and † = <i>p</i> < 0.05 for within group comparisons across time points (as determined using a One-way ANOVA). For IgM comparisons between groups, <i>p</i> = 0.07 and <i>p</i> = 0.08 at weeks 4 and 9, respectively. For IgM comparisons within the control group, <i>p</i> = 0.08. White boxes = SCD, black boxes = controls.