Relative EVI analysis and cancer relevance.

<p>(A, B) Correlation of the relative changes of TR and EVI comparing cancer with normal cells. A549/HBE (A) and H1299/HBE (B) results were shown, respectively; the genes with relative EVIs of greater than ±10 folds were indicated by blue dots. (C,D) Comparative proteomics analyses on the low-EVI genes comparing A549 cells with HBE cells. Relative abundance distributions of total proteins (C) and the unfolded proteins (D) are shown. (E, F) Top canonical pathway analysis of low relative EVIs by IPA. Low relative EVI genes (<10 folds) in A549/HBE (E) and H1299/HBE (F) comparisons were subjected to IPA analysis. The top canonical pathways with <i>P</i> < 0.001 (Fisher’s exact test provided by IPA indicated by the threshold line in orange) regulated by of these genes were shown respectively. The complete gene lists for IPA are included in the <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005901#pgen.1005901.s002" target="_blank">S2 Table</a> with HGNC gene names.