Transcriptional logic of evolved networks.

<p>Comparison between the logic rules in majority rule networks (blue) and clock networks (red), evolved with (solid) or without (hashed/dashed) gene duplications. (A) The relative frequencies among the eight rules that have only two inputs. (B) The structure of logic rules with up to 9 inputs, computed as the mean <i>nested canalizing depth</i> [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150340#pone.0150340.ref021" target="_blank">21</a>] normalized by the number of inputs. (C) The degree distribution of panel B. All three panels indicate that network function is a major factor in determining the distribution of transcriptional logic rules. The transcription rates, which were modelled as continuous functions of TF concentration levels, were discretized into Boolean logic rules as decribed in Methods. Data from 100 networks of each kind.