TGF-β signalling in the renal tubulointerstitium.

<p>A, Counting of p-SMAD2/3-positive nuclei in tubulointerstitial cells of wild type and <i>Itga8</i>-/- mice after induction of unilateral ureter obstruction (UUO). B, Exemplary photomicrographs of renal sections show staining for p-SMAD2/3. C, Western blot analysis comparing p-SMAD protein levels in both genotypes after UUO. <i>Itga8</i>+/+, wild type mice; <i>Itga8</i>-/-, <i>Itga8</i>-deficient mice. Data are means±SEM. # p<0.05 UUO versus control (co), * p<0.05 <i>Itga8</i>+/+ versus <i>Itga8</i>-/-.