Non-neutral local over-representation correlations result in phenotypes being more likely to be found multiple times around genotypes.

<p>We present results for the three GP maps: A) RNA20, B) <i>S</i>_3,8 and C) HP5x5. We pick the same frequent phenotypes <i>q</i> in each of our biological GP maps as used in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004773#pcbi.1004773.g004" target="_blank">Fig 4</a>, and consider the prevalence of <i>q</i> around genotype <i>g</i> with phenotype <i>p</i>, <i><b>given that <i>q</i> occurs at least once</b></i> in the 1-mutation neighbourhood of <i>g</i>. The average of across the <i>n</i> = 10 most frequent phenotypes <i>p</i> in the neighbourhood of <i>q</i> (with <i>p</i> ≠ <i>q</i> and <i>p</i> ≠ del), is compared to the respective averages for random null expectations and defined in the text. The mean of each distribution is plotted as a dotted line in each case. Contiguous sections with a probability greater than 10⁻⁵ are joined with lines in order to guide the eye. The mean value of <i>m</i> for each of the biological GP maps and the two random controls are shown as respective dotted lines with the same colours. Compared to the two null expectations of occurrence, <i>q</i> is over-represented locally as demonstrated by the shift of the means to the right.