Plot showing correlation between clinical patient data and the metabolite features characterizing BSI.

<p>The plot consists of 2 panels: (i) in the lower panel, the color and size of the circles correspond to the strength of the correlation, with increasing circle size and color intensity indicating increasing correlation; shades of blue are used for negative correlations and shades of red for positive correlations, crosses indicate correlations that were statistically insignificant (p-value < 0.05), and (ii) the upper panel shows the corresponding Pearson’s correlation coefficient r. The left labels for metabolites include the feature ID of the metabolite as listed in S1 data and one putative identification. The following eight patient variables were included: confirmed BSI = confirmed or no confirmed BSI diagnosis; malaria = positive or negative malaria blood smear; parasite density = number of asexual <i>Plasmodium</i> parasites in the bloodstream (x10³/mL); disease duration = duration illness prior to hospital admission expressed in days; non-survival = clinical outcome survival or no survival; age = age expressed in months; Hb = blood hemoglobin level (g/dL); % neutrophils = neutrophils as % of total WBC. Lipids are abbreviated with PC, PE, SL, DG or TG for phosphatidylcholines, phosphatidylethanolamines, sphingolipids, diacylglycerides and triacylglycerides respectively, and the total number of acyl side-chain carbons and the double bonds in the side-chains.