Znf3 is required for transposon silencing.

<p>(A) Quantitative real-time PCR showed that deletion of Znf3 or Qip1 resulted in markedly increased abundance of transposon-derived transcripts, similar to mutation of other canonical components of the RNAi pathway. Strains used: H99 and JF289<b>a</b> (wild type), YPH348 and YPH351 (<i>rdp1</i>Δ), YPH738 and YSB299 (<i>ago1</i>Δ), XW205 and MF65 (<i>znf3</i>Δ), and SEC1 and SEC3 (<i>qip1</i>Δ). (B) Heat map of differentially expressed genes in a wild type cross versus a bilateral <i>znf3</i>Δ x <i>znf3</i>Δ cross or a bilateral <i>rdp1</i>Δ x <i>rdp1</i>Δ cross. Strains used: H99 and JF289<b>a</b> (wild type), XW205 and MF65 (<i>znf3</i>Δ), YPH348 and YPH351 (<i>rdp1</i>Δ).