Analysis of (a) IL6, (b) IL6R, (c) STAT3, (d) STAT3-S727, (e) STAT3-Y705, (f) JAK2, (g) JAK2 phosphorylated (Y1007+Y1008), (h) NF-κB (p105/p50), and (i) AKT1 overall expression in animals exposed to FA and O3. Data expressed as Ranks-Kruskal-Wallis test of densitometric analysis; the values are depicted as mean with SD; here, **p ≤ 0.01 and ****p ≤ 0.0001 are the levels of statistical significance compared to controls (n = 6–8 per group). (TIF 2773 kb
Effect of O3 on GSR expression in the lungs of WT and TLR4−/− mice. WT and TLR4−/− mice were exposed...
Increased immune cells and total protein in BALF in both WT and IL-1β−/− groups 24 h after the last ...
Figure S2. Upregulation of IL6 by E2 treatment regulates aggressiveness H1793 tumor cells. Autocrine...
Figure S2. Sex differences in networks affected by differentially expressed miRNAs. Diagram of biolo...
Figure S1. Sex differences in inflammatory miRNA expression. A. Cluster analysis of 84 inflammatory ...
Figure S1. Bar graph showing ELISA analyses on IL6 release from human vascular endothelial cells dur...
Blockade of IL-6 at early inflammatory stage of BLM-injured lung affects TGF-β1 induction in the lun...
<p>Figure 5: Effect of ISO-1 and dexamethasone on ozone-induced lung inflammation. Cytokine mRNA (A,...
BAL neutrophil counts at 48 h post-O3exposure in WT and TLR4−/− mice. WT and TLR4−/− mice were expos...
Age-related effect of O3 on Glutathione reductase (GSR) expression. GSR expression was analyzed in l...
Supplementary Methods. Figure S1. Analysis of Share and Unique Structure (SUS) between OPLS-DA model...
Figure S3. Phosphorylation of STAT3Tyr705 in response to increasing concentration of (A) IL-6 alone ...
Immunohistochemical staining of positive and negative controls. A) Representative 40X image of posit...
Text S1. Set-based model invalidation and parameter estimation. Text S2. Mathematical modelling. Tex...
Table S1. Heterogeneity indeces (I2) for proteins significantly altered between Smoker vs COPD group...
Effect of O3 on GSR expression in the lungs of WT and TLR4−/− mice. WT and TLR4−/− mice were exposed...
Increased immune cells and total protein in BALF in both WT and IL-1β−/− groups 24 h after the last ...
Figure S2. Upregulation of IL6 by E2 treatment regulates aggressiveness H1793 tumor cells. Autocrine...
Figure S2. Sex differences in networks affected by differentially expressed miRNAs. Diagram of biolo...
Figure S1. Sex differences in inflammatory miRNA expression. A. Cluster analysis of 84 inflammatory ...
Figure S1. Bar graph showing ELISA analyses on IL6 release from human vascular endothelial cells dur...
Blockade of IL-6 at early inflammatory stage of BLM-injured lung affects TGF-β1 induction in the lun...
<p>Figure 5: Effect of ISO-1 and dexamethasone on ozone-induced lung inflammation. Cytokine mRNA (A,...
BAL neutrophil counts at 48 h post-O3exposure in WT and TLR4−/− mice. WT and TLR4−/− mice were expos...
Age-related effect of O3 on Glutathione reductase (GSR) expression. GSR expression was analyzed in l...
Supplementary Methods. Figure S1. Analysis of Share and Unique Structure (SUS) between OPLS-DA model...
Figure S3. Phosphorylation of STAT3Tyr705 in response to increasing concentration of (A) IL-6 alone ...
Immunohistochemical staining of positive and negative controls. A) Representative 40X image of posit...
Text S1. Set-based model invalidation and parameter estimation. Text S2. Mathematical modelling. Tex...
Table S1. Heterogeneity indeces (I2) for proteins significantly altered between Smoker vs COPD group...
Effect of O3 on GSR expression in the lungs of WT and TLR4−/− mice. WT and TLR4−/− mice were exposed...
Increased immune cells and total protein in BALF in both WT and IL-1β−/− groups 24 h after the last ...
Figure S2. Upregulation of IL6 by E2 treatment regulates aggressiveness H1793 tumor cells. Autocrine...