Outline of the algorithm.

<p>We aim to describe the immunogenicity of a peptide:HLA combination as a number between 0 and 1. For each subject, the outcome of the ELISpot assay is known, together with a list of their HLA alleles. The user can add prior knowledge in the form of a prior distribution. In the example, the prior knowledge describes the belief that HLA class II allele <i>A</i> is not immunogenetic in combination with the peptide, while HLA class-II allele <i>B</i> is. The output of the algorithm consists of posterior marginal distributions of the values <i>E</i>_<i>j</i>. In the example, it is found that allele <i>A</i> is more immunogenic that allele <i>B</i> in combination with the peptide.