Copper-Catalyzed Multicomponent Domino Reaction of 2‑Bromoaldehydes, Benzylamines, and Sodium Azide for the Assembly of Quinazoline Derivatives

Cheng Xu (352754)
Feng-Cheng Jia (1662109)
Zhi-Wen Zhou (650404)
Si-Jie Zheng (2563534)
Han Li (10885)
An-Xin Wu (1393744)

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Publication date

March 2016

DOI

10.1021/acs.joc.5b02843.s002

ISSN

0022-3263

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Abstract

An efficient three-component domino reaction of 2-bromoaldehydes, benzylamines, and sodium azide has been developed for the synthesis of quinazoline derivatives. This domino process involves copper-catalyzed S<sub>N</sub>Ar, oxidation/cyclization, and denitrogenation sequences. The mild catalytic system enabled the effective construction of three C–N bonds in one operation

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Copper-Catalyzed Multicomponent Domino Reaction of 2‑Bromoaldehydes, Benzylamines, and Sodium Azide for the Assembly of Quinazoline Derivatives

Abstract

Extracted data

Copper-Catalyzed Multicomponent Domino Reaction of 2‑Bromoaldehydes, Benzylamines, and Sodium Azide for the Assembly of Quinazoline Derivatives

Abstract

Extracted data

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