H3K27 trimethylation regulates <i>WNT5A</i> expression in response to UPEC infection.
- Kenneth Ting (2559154)
- Karen J. Aitken (442776)
- Frank Penna (2559139)
- Alaleh Najdi Samiei (2559136)
- Martin Sidler (2559142)
- Jia-Xin Jiang (442775)
- Fadi Ibrahim (2559145)
- Cornelia Tolg (397037)
- Paul Delgado-Olguin (2559151)
- Norman Rosenblum (2559148)
- Darius J. Bägli (442780)
Publication date
March 2016
DOIAbstract
<p>QPCR (<sup><b>ΔΔ</b></sup>c(t) method) was performed to detect EZH2 vs. reference gene expression. UPEC infection induced expression of <i>WNT5A</i> at 18 hours post-inoculation with 2 moi of UPEC Fim H<sup>+</sup> bacteria compared to mock infected cells (*, p<0.05). The UPEC-induced <i>WNT5A</i> expression was reduced by treating with the EZH2 inhibitor UNC1999 (*,p<0.05) and increased further with the KDM6A/B inhibitor GSK J4 (**, vs. all other columns, p<0.05). N = 5.</p
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