Effect of A779 on colitis severity.

<p>Panel A shows % body weight change in untreated (UT; hatched line, solid circles) or DSS treated (for 4 days) mice given daily i.p injections of A779 (gray line, open squares) or saline (gray line, solid squares). Panel B shows % of circulating lymphocytes and neutrophils determined at day 4 post DSS colitis induction in A779 (open bars) or saline treated mice (hatched bars) compared to UT group (solid bars). Colon length (panel C) and thickness (panel D) was determined in A779 (open bars) or saline (hatched bars) treated mice compared to UT group (solid bars). Panels E and F represent histological assessment of colitis severity and the % of ulceration in the whole colon section respectively in the groups indicated. Histobars represent means ± SEM for 5–9 mice in each group (9 for UT and 5 for DSS/i.p saline and DSS/A779). Asterisks denote significant difference from UT mice with p<0.05 and # denotes significant difference from DSS/ i.p saline treated group with p<0.05. Panels G and H show representative colon sections from DSS/i.p saline or DSS/A779 treated mice.