Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces - Fig 6

<p>A) Plot of the fraction of bivalently bound sites as a function of the apparent (face-value) hapten density. Shaded regions correspond to the prediction of our model, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004752#pcbi.1004752.e011" target="_blank">Eq (8)</a>, for values of the Fab arm length between 6 and 7 nm (lower and upper curves delimiting the filled regions). Symbols are the experimental data reported in [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004752#pcbi.1004752.ref032" target="_blank">32</a>]. B) Plot of the fraction of bivalently bound <i>molecules</i> as a function of the rescaled surface density of haptens, . For the numerical data, the values reported in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004752#pcbi.1004752.t001" target="_blank">Table 1</a> were used. For the experimental data from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004752#pcbi.1004752.ref032" target="_blank">32</a>], we used the value reported in the paper mol/m². The theoretical prediction (<i>x</i>/(2 + <i>x</i>)) is given by the Langmuir isotherm <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004752#pcbi.1004752.e020" target="_blank">Eq (12)</a>.