Diagram of model for the pathogenesis during acute pulmonary tuberculosis infection.

<p>We consider three different physiological compartments for the location of TB bacteria: host macrophages (M), granulomas (G) and open cavities (OC). The base replication rate <i>r</i> of the bacteria is modified by a compartment specific parameter γ. The bacteria die with a density-dependent rate <i>d</i> and migrate from one compartment to another at a rate <i>m</i>.