SD dynamics in model system consisting of a neuron, glial compartment, and the ECS.

<p>SD is initiated by interrupting pump activity and glial ion regulation for 20 sec (shaded or hatched region). In <b>(a)</b> the evolution of potentials is shown. During pump interruption the cell depolarizes and differences between <i>V</i>, <i>E</i>_<i>K</i> and <i>E</i>_<i>Na</i> become small. The system repolarizes abruptly and potential differences are rebuilt after about 150 sec (repolarization point indicated by vertical pink line and a star). The volume of the whole system and the respective portion of the neuron, ECS, and the glia cell are shown in <b>(b)</b>. Relative changes of the three compartments and the full system are shown in <b>(c)</b> with an inset for finer resolution between 40 sec and 110 sec.