Treatment of melanoma B16-bearing mice with isRNA inhibits primary tumor growth.

<p>C57BL/6 mice with subcutaneous melanoma (1.5 × 105 cells per mouse) were treated with isRNA/2X3-DOPE complexes (p.t. or i.v. injections). (A) Dynamics of tumor growth. Black arrows indicate days of isRNA administration. The data represent mean ± SEM (n = 8–10). Statistically significant differences between experimental groups and the untreated group (control) are indicated by asterisks (**, P<0.01; *, P<0.05); and between experimental groups and the 2X3-DOPE-treated group by crosses (††, P<0.01; †, P<0.05); Mann-Whitney U test. (B) MR images of the representative mice from different groups on day 17 after tumor initiation. Frontal longitudinal sections with the maximum size of tumors from each group are shown. White arrows indicate tumor nodes.