Aims: To provide a brief critical review of the basis and contemporary practice of monitoring the concentrations of antiepileptic drugs in biological fluids. Methods: The review is based on literature data and observations from clinical practice. Results: As experience has accumulated, monitoring of antiepileptic drug concentrations has come to be applied mainly to certain of the drugs when present in whole plasma. For these drugs there is a reasonably established relationship between drug concentrations and biological effects, but attention still needs to be paid to issues such as the timing of the measurements in relation to drug intake, the presence or absence of steady-state conditions, the presence in plasma of active metabolites and p...
Plasma anticonvulsant drug concentration monitoring has considerable potential to make the therapy o...
Objective. To define therapeutic drug monitoring (TDM) role when using drugs of valproic acid and a ...
Epilepsy is a widely diffused neurological disorder including a heterogeneous range of syndromes wi...
Aims: To provide a brief critical review of the basis and contemporary practice of monitoring the co...
This review focuses on a clinical evaluation of drug monitoring in the therapy of epilepsy by antiep...
The plasma concentrations of anticonvulsant drugs, and of certain of their biologically active metab...
Commonly used conventional antiepileptic drugs for pharmacotherapy in epilepsy are phenytoin, carbam...
Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (T...
A multi-center survey of antepileptic treatment was conducted in Italy on 245 previously untreated (...
Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 3...
The plasma levels of various anticonvulsant drugs provide a measure of their concentration in the br...
Therapeutic drug monitoring (TDM) has been recognized as a useful guide in the clinical management o...
Background: Therapeutic drug monitoring is a beneficial tool to supervise patients when they do not ...
When monitoring of the plasma concentrations of anticonvulsant drugs first came into use 25 years ag...
Rates for being free of all epileptic seizures for at least 1 year and for ceasing therapy after 3–5...
Plasma anticonvulsant drug concentration monitoring has considerable potential to make the therapy o...
Objective. To define therapeutic drug monitoring (TDM) role when using drugs of valproic acid and a ...
Epilepsy is a widely diffused neurological disorder including a heterogeneous range of syndromes wi...
Aims: To provide a brief critical review of the basis and contemporary practice of monitoring the co...
This review focuses on a clinical evaluation of drug monitoring in the therapy of epilepsy by antiep...
The plasma concentrations of anticonvulsant drugs, and of certain of their biologically active metab...
Commonly used conventional antiepileptic drugs for pharmacotherapy in epilepsy are phenytoin, carbam...
Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (T...
A multi-center survey of antepileptic treatment was conducted in Italy on 245 previously untreated (...
Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 3...
The plasma levels of various anticonvulsant drugs provide a measure of their concentration in the br...
Therapeutic drug monitoring (TDM) has been recognized as a useful guide in the clinical management o...
Background: Therapeutic drug monitoring is a beneficial tool to supervise patients when they do not ...
When monitoring of the plasma concentrations of anticonvulsant drugs first came into use 25 years ag...
Rates for being free of all epileptic seizures for at least 1 year and for ceasing therapy after 3–5...
Plasma anticonvulsant drug concentration monitoring has considerable potential to make the therapy o...
Objective. To define therapeutic drug monitoring (TDM) role when using drugs of valproic acid and a ...
Epilepsy is a widely diffused neurological disorder including a heterogeneous range of syndromes wi...