Mechanics in 9-month old mice.

<p>(A) Static (E_st) and (B) dynamic (E_dyn) elastances in WT (white column) and Marfan mice (grey column) determined by the end-inspiratory airway occlusion method. *: p < 0.05 when comparing WT and Marfan. (C) Young’s modulus (E) measured at different regions of the lung ECM in WT (white column) and Marfan mice (grey column). #: p < 0.05, and •: p < 0.05 when comparing different regions in WT and Marfan, respectively. (D) Complex shear modulus (G*) measured at the alveolar septum of decellularized lung matrix in WT (open symbols) and MFS (closed symbols) mice. Circles represent the real part (storage modulus, G’) and triangles represent the imaginary part (loss modulus, G”) of G*. Solid and dashed lines represent fits of the two power law model to G’ and G”, respectively (WT black and MFS grey). Data are mean ± SE.