Lytic replication in the lungs after i.n. inoculation.

<p>C57BL/6 mice were inoculated i.n. with 1x 10³ PFU of the indicated viruses. Lungs of mice were harvested at day 3 after infection (parental virus or mutant viruses) and at day 6 after infection (parental or mutant viruses and ectopic revertants). Virus titers were determined from organ homogenates by plaque assay. Each symbol represents an individual mouse, and the bars represent the median value. (A) The data are compiled from two (day 3) and five (day 6 mutant viruses) or six (day 6 parental virus) independent experiments. (B and C) The data are compiled from two independent experiments in each case. The asterisks indicate a statistically significant difference between the groups (* P < 0.05; ** P < 0.01; *** P < 0.001).