RBP2 directly targets the promoter of BCL2.

<p>(A) Predicted binding sites of RBP2 in the BCL2 promoter (-1078~-1620) were divided into regions a, b, and c. (B) ChIP assay for binding of RBP2 to BCL2 promoter regions a, b, and c. (C) Luciferase activities of the BCL2 promoter were determined after RBP2-siRNA transfection for 72 h and were normalized by Renilla luciferase activity. The data represent the mean ± SEM (standard error of the mean). An unpaired t-test was performed for statistical analyses; *P< 0.05.