<p>(A) Glucose inhibits FA oxidation in INS-1 cells. [<sup>14</sup>C]oleate oxidation, as described in Methods, was measured in INS-1 cells incubated in 2 mM glucose (<i>white bars</i>) and 8 mM glucose (<i>gray bars</i>). 8 mM glucose inhibits FA oxidation 80% compared to 2 mM glucose control. (B) JQ1 (250–500 nM) increased FA oxidation up to 2-fold in the presence of 8 mM glucose. Oxidation in the presence of inactive JQ1 (R) was set at 100% for both 2 and 8 mM glucose. (A-B n = 3 experiments; * p<0.05).</p
Objective:. There is evidence from in vitro studies that fatty acids can inhibit glucose uptake in l...
Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolis...
Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediat...
We tested the hypothesis that glucose plus insulin deter-mine the rate of fat oxidation in humans by...
Positive acute effects of fatty acids (FA) on glucose-stimulated insulin secretion (GSIS) and reacti...
Skeletal muscle insulin resistance may be aggravated by intramyocellular accumulation of fatty acid-...
The Glucose Fatty Acid Cycle as formulated 30 years ago and reviewed in the Minkowski lecture in 196...
<p>Myotubes were either grown in DMEM-media with 5.5 mM glucose or 5.5 mM galactose during the whole...
International audienceExcess reactive oxygen species (ROS) production is thought to play a key role ...
<p>Levels of protein carbonyls (A) in cells treated with exogenous MG (**<i>P</i><0.01 vs. control),...
The mechanisms responsible for the competition between glucose and fatty acids as oxidative fuels ar...
The key defects characteristic of hyperglycemia in T2D include increased hepatic glucose production,...
In vitro studies indicate that FFA compete with glucose as an oxidative fuel in muscle and, in addit...
Fatty acid (FA) may disturb the redox state of the cells not only by an increase in reactive oxygen ...
<p>Levels of oxidized DCF (A) in cells treated with exogenous MG (**<i>P</i><0.01 vs. control), (B) ...
Objective:. There is evidence from in vitro studies that fatty acids can inhibit glucose uptake in l...
Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolis...
Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediat...
We tested the hypothesis that glucose plus insulin deter-mine the rate of fat oxidation in humans by...
Positive acute effects of fatty acids (FA) on glucose-stimulated insulin secretion (GSIS) and reacti...
Skeletal muscle insulin resistance may be aggravated by intramyocellular accumulation of fatty acid-...
The Glucose Fatty Acid Cycle as formulated 30 years ago and reviewed in the Minkowski lecture in 196...
<p>Myotubes were either grown in DMEM-media with 5.5 mM glucose or 5.5 mM galactose during the whole...
International audienceExcess reactive oxygen species (ROS) production is thought to play a key role ...
<p>Levels of protein carbonyls (A) in cells treated with exogenous MG (**<i>P</i><0.01 vs. control),...
The mechanisms responsible for the competition between glucose and fatty acids as oxidative fuels ar...
The key defects characteristic of hyperglycemia in T2D include increased hepatic glucose production,...
In vitro studies indicate that FFA compete with glucose as an oxidative fuel in muscle and, in addit...
Fatty acid (FA) may disturb the redox state of the cells not only by an increase in reactive oxygen ...
<p>Levels of oxidized DCF (A) in cells treated with exogenous MG (**<i>P</i><0.01 vs. control), (B) ...
Objective:. There is evidence from in vitro studies that fatty acids can inhibit glucose uptake in l...
Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolis...
Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediat...