<p><b>(a)</b> Distribution across families containing only singletons, or with 2–5 members or 6+ members. Paralogous gene families were identified using a network-based approach (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151883#pone.0151883.s021" target="_blank">S1 Text</a>). <b>(b)</b> Definition of COG categories on the x-axis of <b>(a)</b> (and also in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151883#pone.0151883.s007" target="_blank">S4 Fig</a>).</p
<p>(A.) An overview of the manually-curated dataset of 112 tissue-selective hereditary diseases (gra...
<p>Schematic representation of bacterial (A), eukaryotic (B) and archaeal (C) species trees showing ...
Background: In prokaryotic genomes, functionally coupled genes can be organized in conserved gene c...
<p>The functional categorization of each homologous gene clusters was classified according to the CO...
<p>The COG-annotated genes are grouped under their respective COG classes. Only their class abbrevia...
<p>Proportion (FD) is the proportion of tested branches with at least one functionally divergent sit...
In order to extract the maximum amount of information from the rapidly accumulating genome sequences...
<p>Orthologs without any COG annotation were sorted as ‘not determined’. The asterisks indicate stat...
<p>Number of orthologs as a function of the number of genomes they are in, broken down by super-func...
<p>Capital letters on X-axis indicated the COG categories as listed on the right of the histogram; Y...
<p>CpG motif frequencies in upstream domains of gene sets for KEGG functional classes. There are fiv...
<p>Open circles in network are hypothesized but not sampled haplotypes. Abbreviations are as in <a h...
<p>All putative proteins were aligned to the COG database and could be classified into at least 25 m...
<p>The functional categories are information storage and processing, including COG categories J, K, ...
<p>Panels (A) and (B) are based on all protein-coding genes, panels (C) and (D) are based on the put...
<p>(A.) An overview of the manually-curated dataset of 112 tissue-selective hereditary diseases (gra...
<p>Schematic representation of bacterial (A), eukaryotic (B) and archaeal (C) species trees showing ...
Background: In prokaryotic genomes, functionally coupled genes can be organized in conserved gene c...
<p>The functional categorization of each homologous gene clusters was classified according to the CO...
<p>The COG-annotated genes are grouped under their respective COG classes. Only their class abbrevia...
<p>Proportion (FD) is the proportion of tested branches with at least one functionally divergent sit...
In order to extract the maximum amount of information from the rapidly accumulating genome sequences...
<p>Orthologs without any COG annotation were sorted as ‘not determined’. The asterisks indicate stat...
<p>Number of orthologs as a function of the number of genomes they are in, broken down by super-func...
<p>Capital letters on X-axis indicated the COG categories as listed on the right of the histogram; Y...
<p>CpG motif frequencies in upstream domains of gene sets for KEGG functional classes. There are fiv...
<p>Open circles in network are hypothesized but not sampled haplotypes. Abbreviations are as in <a h...
<p>All putative proteins were aligned to the COG database and could be classified into at least 25 m...
<p>The functional categories are information storage and processing, including COG categories J, K, ...
<p>Panels (A) and (B) are based on all protein-coding genes, panels (C) and (D) are based on the put...
<p>(A.) An overview of the manually-curated dataset of 112 tissue-selective hereditary diseases (gra...
<p>Schematic representation of bacterial (A), eukaryotic (B) and archaeal (C) species trees showing ...
Background: In prokaryotic genomes, functionally coupled genes can be organized in conserved gene c...