Multiple STZ injection induces rat developed stable type 2 diabetes with insulin resistant.

<p>(A) BG levels were determined every week after diabetic induction. Data are shown as the mean ± SD. ***<i>p<0</i>.<i>001</i>, <i>n = 60</i>. (B) 4wks after diabetic induction control group and diabetic group were starved for 16hs. serum insulin levels were determined by ELISA depicted as previously. (C-D) 4wks after diabetic induction serum starved and non-starved cholesterol and triglycerides levels of both groups were determined. (E, F) Pancreas tissues from both control and diabetic rats were collected when terminational experiment was performed and animal was euthanatized. E. Representative hematoxylin-eosin (H&E) staining section of pancreatic tissue. F. Representative images for immunohistochemical staining of insulin in the pancreatic tissue.