Additional file 5: Figure S5. of Shared genetic control of expression and methylation in peripheral blood

Relationship between the observed (x-axis) and predicted (y-axis) cell proportions in the BSGS dataset split by cell type. Cell proportions were predicted utilizing methylation data with Houseman et al. [21] method re-trained on Reinius et al. [19] dataset. The predicted proportions were calibrated on the 422 subsample that have cellular composition measured to have a slope equal one and an intercept equal zero when regressed on observed proportions (see Table S1 for correlations between observed and predicted proportions). The red line is an identity line. (PDF 27 kb