<p><b>(A)</b> Disulfiram is metabolized to diethyldithiocarbamate (DDC) and DDC complexes with Copper (Cu) (II). <b>(B)</b> Cytotoxicity curves for DSF (●) and DSF + CuSO<sub>4</sub> (■) were obtained with the IN CELL Analyzer using U87 glioblastoma cells where cell viability was assessed based on loss of plasma membrane integrity 72 hours following treatment; i.e. total cell count and dead cell count were determined using Hoechst 33342 and ethidium homodimer staining, respectively. <b>(C)</b> Cytotoxicity curves for DDC (●) and DDC + CuSO<sub>4</sub> (■); where cytotoxicity was measured as described above. <b>(D)</b> DDC and Cu(DDC)<sub>2</sub> IC<sub>50</sub> for U251, MDA-231-BR, and A549 cancer cell lines as well as HBEcP a normal cell ...
study and providing very important information in his letter. In order to apply disufiram (DS) in ca...
Disulfiram (DSF) is an aldehyde dehydrogenase inhibitor currently used for the treatment of alcoholi...
Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to ...
The anticancer activity of disulfiram (DS) is copper(II) (Cu)-depen-dent. This study investigated th...
AbstractIt is a therapeutic strategy for cancers including pancreatic to inhibit proteasome activity...
Diethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse...
Copper (Cu) plays a pivotal role in cancer progression by acting as a co-factor that regulates the a...
The use of chelators for cancer treatment has been an alternative option. Dithiocarbamates have rece...
Mohamed Wehbe,1,2 Malathi Anantha,1 Minghan Shi,3,4 Ada Wai-yin Leung,1 Wieslawa H Dragowska,1 L&eac...
Abstract Background Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer acti...
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as...
AbstractDithiocarbamates are nitrogen- and sulfur-containing compounds commonly used in pharmacology...
Abstract Disulfiram has been used for several decades in the treatment of alcoholism. It now shows p...
The alcohol-abuse deterrent disulfiram (DSF) is shown to have a highly selective toxicity against me...
Copper is an essential trace element for living organisms and, in particular, is the third most abun...
study and providing very important information in his letter. In order to apply disufiram (DS) in ca...
Disulfiram (DSF) is an aldehyde dehydrogenase inhibitor currently used for the treatment of alcoholi...
Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to ...
The anticancer activity of disulfiram (DS) is copper(II) (Cu)-depen-dent. This study investigated th...
AbstractIt is a therapeutic strategy for cancers including pancreatic to inhibit proteasome activity...
Diethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse...
Copper (Cu) plays a pivotal role in cancer progression by acting as a co-factor that regulates the a...
The use of chelators for cancer treatment has been an alternative option. Dithiocarbamates have rece...
Mohamed Wehbe,1,2 Malathi Anantha,1 Minghan Shi,3,4 Ada Wai-yin Leung,1 Wieslawa H Dragowska,1 L&eac...
Abstract Background Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer acti...
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as...
AbstractDithiocarbamates are nitrogen- and sulfur-containing compounds commonly used in pharmacology...
Abstract Disulfiram has been used for several decades in the treatment of alcoholism. It now shows p...
The alcohol-abuse deterrent disulfiram (DSF) is shown to have a highly selective toxicity against me...
Copper is an essential trace element for living organisms and, in particular, is the third most abun...
study and providing very important information in his letter. In order to apply disufiram (DS) in ca...
Disulfiram (DSF) is an aldehyde dehydrogenase inhibitor currently used for the treatment of alcoholi...
Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to ...