The lack of catabolite inactivation in <i>C</i>. <i>albicans</i> permits simultaneous assimilation of alternative carbon sources and glucose.

<p>In <i>S</i>. <i>cerevisiae</i>, glucose triggers the rapid ubiquitination and degradation via the GID complex of enzymes involved in the assimilation of alternative carbon sources (catabolite inactivation). Consequently, <i>S</i>. <i>cerevisiae</i> displays sequential assimilation of these carbon sources, only utilizing alternative carbon sources once glucose has been exhausted. In contrast, <i>C</i>. <i>albicans</i> enzymes involved in the utilization of alternative carbon sources lack ubiquitination sites and hence are not subject to catabolite inactivation. Consequently, these pathways remain active in <i>C</i>. <i>albicans</i> following glucose exposure and this yeast displays simultaneous assimilation of alternative carbon sources and glucose [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005566#ppat.1005566.ref018" target="_blank">18</a>].