CD4 phosphorylation-guided intracellular trafficking of HIV determines activation of signaling pathways.

<p>Bar graphs represent 3 experiments with mean ± SD of CD4-transduced HEK-blue hTLR7 cells incubated with CpGB, HIV, or R848 overnight with NF-kB activation expressed as fold change (O.D.) over unstimulated cells. NF-kB activation is compared between HEK cells not expressing CD4 (-) 0.58±0.05 as compared to HEK cells expressing SA CD4 0.93±0.04 as compared to HEK cells expressing SE CD4 2.26±0.26 as compared to HEK cells expressing WT CD4 0.73±0.0, unpaired Student’s t test *p<0.05.