The role of tissue architecture in mediating nanoparticle transport, targeting, and biological effects is unknown due to the lack of tools for imaging nanomaterials in whole organs. Here, we developed a rapid optical mapping technique to image nanomaterials in intact organs <i>ex vivo</i> and in three-dimensions (3D). We engineered a high-throughput electrophoretic flow device to simultaneously transform up to 48 tissues into optically transparent structures, allowing subcellular imaging of nanomaterials more than 1 mm deep into tissues which is 25-fold greater than current techniques. A key finding is that nanomaterials can be retained in the processed tissue by chemical cross-linking of surface adsorbed serum proteins to the tissue matrix...
Deciphering biodistribution, biokinetics, and biological effects of nanoparticles (NPs) in entire or...
Super-resolution fluorescence microscopy, also known as nanoscopy, has provided us with a glimpse of...
We present a 3D study of nanostructural features of a bioprinted tissue spheroid interacting with po...
The role of tissue architecture in mediating nanoparticle transport, targeting, and biological effec...
Chemical probes are key components of the bioimaging toolbox, as they label biomolecules in cells an...
Nanomedicines are sub-micrometer-sized carrier materials designed to improve the biodistribution of ...
While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously pr...
Many diseases are characterized by nanostructural changes in connective fibers and soluble proteins,...
Using near-infrared femtosecond pulses, we move single gold nanoparticles (AuNPs) along biological f...
Nanomaterials are used for numerous biomedical applications, but the selection of optimal properties...
The structure of solid tumours is a major factor contributing to poor treatment outcomes because it ...
Knowledge of the interactions between nanomaterials and large-size mammalian cells, including cellul...
We developed an optical imaging method based on a feedback principle in which the specific scan patt...
Bioimaging is a broad term that covers all processes in which biological tissues are imaged. It can ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.Ca...
Deciphering biodistribution, biokinetics, and biological effects of nanoparticles (NPs) in entire or...
Super-resolution fluorescence microscopy, also known as nanoscopy, has provided us with a glimpse of...
We present a 3D study of nanostructural features of a bioprinted tissue spheroid interacting with po...
The role of tissue architecture in mediating nanoparticle transport, targeting, and biological effec...
Chemical probes are key components of the bioimaging toolbox, as they label biomolecules in cells an...
Nanomedicines are sub-micrometer-sized carrier materials designed to improve the biodistribution of ...
While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously pr...
Many diseases are characterized by nanostructural changes in connective fibers and soluble proteins,...
Using near-infrared femtosecond pulses, we move single gold nanoparticles (AuNPs) along biological f...
Nanomaterials are used for numerous biomedical applications, but the selection of optimal properties...
The structure of solid tumours is a major factor contributing to poor treatment outcomes because it ...
Knowledge of the interactions between nanomaterials and large-size mammalian cells, including cellul...
We developed an optical imaging method based on a feedback principle in which the specific scan patt...
Bioimaging is a broad term that covers all processes in which biological tissues are imaged. It can ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.Ca...
Deciphering biodistribution, biokinetics, and biological effects of nanoparticles (NPs) in entire or...
Super-resolution fluorescence microscopy, also known as nanoscopy, has provided us with a glimpse of...
We present a 3D study of nanostructural features of a bioprinted tissue spheroid interacting with po...