Targeted lipidomic analysis of COX products in adipose tissue from control and obese individuals.
- Verónica García-Alonso (2636572)
- Esther Titos (2636563)
- Jose Alcaraz-Quiles (2636569)
- Bibiana Rius (2636560)
- Aritz Lopategi (2636554)
- Cristina López-Vicario (2636575)
- Per-Johan Jakobsson (356891)
- Salvadora Delgado (354863)
- Juanjo Lozano (2636566)
- Joan Clària (2636557)
Publication date
April 2016
DOIAbstract
<p><b>(A)</b> Levels of PGE<sub>2</sub>, 15d-PGJ<sub>2</sub>, 6-keto-PGF<sub>1α</sub> and PGF<sub>2α</sub> in adipose tissue from non-obese control individuals (n = 6) and obese patients (n = 7) were assessed by LC-ESI-MS/MS. <b>(B)</b> COX-2, mPGES-1, mPGES-2 and cPGES expression in omental adipose tissue from control (n = 7) and obese (n = 11) individuals. <b>(C)</b> Representative Western blot of mPGES-1 protein expression in omental adipose tissue. <b>(D)</b> Correlation between the expression of COX-2 and mPGES-1 in omental adipose tissue and the body mass index (BMI). The results are expressed as mean ± SEM. *, P<0.05 and **, P<0.01 versus control.</p
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