<i>T</i>. <i>cruzi</i> induces the transcription of immunoproteasome genes in mice and humans.

<p>Relative quantification (RQ) of the indicated mRNA levels was measured by real-time PCR in myocardial tissue samples from (a) WT mice infected with <i>T</i>. <i>cruzi</i> (Y strain) 12 dpi or from (b) chronic chagasic patients with cardiomyopathy as compared to samples obtained from <i>naïve</i> mice or healthy subjects, respectively. Results are shown as individual values and as the mean ± SEM for each group. For mouse groups, n = 5, pooled from two independent experiments, and for human samples, n = 14. Asterisks indicate that the values observed for immunoproteasome genes were significantly higher than those for conventional proteasome genes (*P<0.05 ***P<0.001 ****P<0.0001).