Simulated response to block of K_ATP channel in type 2 diabetes (T2D).

<p>(A) K_ATP channel current (<i>I</i>_KATP), (B) PM potential (V_p); (C) [Ca²⁺]_c. T2D conditions were simulated by a decrease of the coefficient that is responsible for glucose dependent saturated ATP/ADP ratio (ATD_m, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152869#pone.0152869.e004" target="_blank">Eq 4</a>). ATD_m was decreased from 32 (basal level) to 15. In this case PM membrane potential does not increase up to the nessesary threshold and does not lead to [Ca²⁺]_c increase as glucose is increased from 3 mM to 8 mM at 1000 sec. For simulation of K_ATP channel blocking the maximal conductance (g_mKATP, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152869#pone.0152869.e009" target="_blank">Eq 9</a>) was decreased from 24 nS (basal level) to 9 nS at 3000 sec. This induces additional PM depolarization and fast [Ca²⁺]_c increase.