Interplay between the 500-bp interspersed homology 4H-7N_1 and different patterns of interspersed homology in the adjacent 100-bp region.

<p>(a) Reference/test combinations are created for a region derived from the 100-bp insert (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006015#pgen.1006015.g002" target="_blank">Fig 2D</a>: construct v). All interspersed homologies (as described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006015#pgen.1006015.g001" target="_blank">Fig 1</a>) have a homologous unit length of 6 base-pairs and are varied with respect to periodicity (from 8 to 15) and sequence position (from 1 to 12, for the selected periodicity of 10). We note that the last homologous unit in 6H-4N_2, 6H-4N_3 and 6H-4N_4 was inadvertently extended by 3, 2 and 1 base-pairs, respectively. (b) The mean number of RIP mutations (measured as in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006015#pgen.1006015.g002" target="_blank">Fig 2C</a>) for repeat constructs described in (Panel a). (c) RIP mutation profiles for selected repeat constructs with periodicities of 8, 9, 10 and 11, corresponding to homology patterns 6H-2N_1, 6H-3N_1, 6H-4N_1 and 6H-5N_1, respectively, as described in (Panel a). (d) RIP mutation profiles for selected repeat constructs with sequence positions of 3, 5, 9, and 11, and corresponding to homology patterns 6H-4N_3, 6H-4N_5, 6H-4N_9 and 6H-4N_11, respectively, as described in (Panel a).