Poster OARSI 2016: Aggravated osteoarthritis development on a high fat diet in mice transgenic for human C-reactive protein

Metabolic overload is linked to OA development. The low-grade systemic inflammation associated with metabolic overload is a possible mechanism through which OA pathogenesis is mediated. Using a mouse strain transgenic for the human inflammation marker C-reactive protein (hCRP), we questioned whether inflammation plays a role in disease development in a murine metabolic OA model