Examples of individual follow-up of miR-122 with personalized threshold.

<p><b>(A and B)</b> Two examples of longitudinal monitoring of plasma miR-122 with personalized threshold (indicated by continuous black line) for two volunteers with different <i>UGT2B17</i> genotypes (ins/del and ins/ins) after oral and transdermal intake of T. Thresholds are calculated as the mean of the control phase results + 3 × SD. In these examples, longitudinal monitoring of plasma miR-122 levels after oral T administration is more sensitive than of transdermal T administration. Data were normalized against the corresponding levels of endogenous miR-486-5p.