Collateral number shown by X-ray angiograms.

<p>The collateral arteries in group NC (A) and HI (right leg), HD (right leg), and HID (right leg: ischemic and denervated, left leg: ischemic) 7 and 28 days post-surgery (B) are shown. The number of collateral arteries was obtained by counting the arteries that intersected a line that was perpendicular to the midpoint of the femur (shown as a straight line in A). The remodeling collateral arteries are indicated with black arrows. Few pre-existing collaterals was seen in group NC (A). The number of collaterals in group HI significantly increased compared with group NC on day 7 and further increased on day 28 post-surgery (C). The number of collaterals did not change 7 or 28 days post-surgery in group HD (D) compared with group NC. In group HID, the number of collaterals (the right leg) also increased compared with group NC, but the number was lower than group HI on day 7 and 28 post-surgery (E). n = 4 per group * <i>p</i><0.05, *** <i>p</i><0.001.