A new irregular monoterpene acetate along with eight known compounds with antifungal potential from the aerial parts of <i>Artemisia incisa</i> Pamp (Asteraceae)

<p>A new compound named as santolinylol-3-acetate (4-(2-hydroxypropan-2-yl)-2-methylhexa-1,5-dien-3-yl acetate) (<b>3</b>), along with seven known compounds; linoleic acid (<b>1</b>), benzoic acid (<b>2</b>), santolinylol (<b>4</b>), ethyl-(<i>E</i>)-<i>p</i>-hydroxy cinnamate (<b>5</b>), scopoletin (<b>6</b>), esculetin (<b>7</b>) isofraxidin (<b>8</b>) and eupatorin (<b>9</b>), were isolated from the aerial parts (ethanolic extract) of endangered species: <i>Artemisia incisa</i> Pamp (Asteraceae). The compounds’ structures were determined through modern spectroscopic techniques, and comparison of data (physicochemical constants) with the literature. The relative stereochemistry of santolinylol-3-acetate (<b>3</b>) was determined by comparing its data of NOESY, and specific rotation with its diol analogue; santolinylol (<b>4</b>), isolated from the same plant; <i>A. incisa</i>. The results of the antifungal activity showed that coumarins are as whole less active compounds. Compounds <b>3</b> (25 and 300 μg/mL), and <b>4</b> (12.5 and 300 μg/mL), showed good activities against <i>Candida albicans</i>, and <i>Aspergillus flavus</i>, respectively, which justifies <i>A. incisa</i> as a traditional medicine for curing the said fungal infections.</p> <p>Irregular monoterpene activity against Candida albicans infection.